Definition – The inflammasomes are innate immune system receptors and sensors that regulate the activation of
caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins¹.
These are an important component of Innate immunity because they can recognize the molecules released by the pathogen even without any previous exposure from such molecules. The recognition triggers the following chain of events –
The Ultimate result is cell death due to Pyroptosis.
Further Reading –
- Pyroptosis – One type of Inflammatory cell death
- The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
Image Attribution –
- Featured image and CASP-1 – By Emw – Own work, CC BY-SA 3.0, Link,
- Mechanism of Inflammasome action – Arnab Mukherjee, The Paradigm Shift Group. CC BY-SA 3.0,
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