Definition – The inflammasomes are innate immune system receptors and sensors that regulate the activation of

Molecular pattern of Caspase-1

caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins¹.


These are an important component of Innate immunity because they can recognize the molecules released by the pathogen even without any previous exposure from such molecules. The recognition triggers the following chain of events –

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Mechanism of Inflammasome action


The Ultimate result is cell death due to Pyroptosis.


Reference –

Further Reading –

Image Attribution –


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  • Mukherjee Narayan Reply

    Very recently an article of Nature Medicine emphasized the importance of coffee in prevention of cellular ageing, very soon I am going to publish a brief review on this discovery for everyone here. and thank you @Arnab for explaining the mechanism with the diagram, I just want to add a few textbook references in the comment section, so that you can add those in the article later.

  • Robin Williams Reply

    I hate to see how some bloggers in other websites are telling people that taking a load of coffee each day will make you live longer. It is completely an exaggeration and far from the truth. @narayan, I encourage you to write a scientific review as soon as possible.

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