Definition – The inflammasomes are innate immune system receptors and sensors that regulate the activation of

Molecular pattern of Caspase-1
CASP-1

caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins¹.

 

These are an important component of Innate immunity because they can recognize the molecules released by the pathogen even without any previous exposure from such molecules. The recognition triggers the following chain of events –

Oh no! Here should be an image of Inflammasome. Please try with another browser.
Mechanism of Inflammasome action

 

The Ultimate result is cell death due to Pyroptosis.

 

Reference –

Further Reading –

Image Attribution –

 

✨  Note

We continuously update our articles by consulting with the author and changes in recent guidelines of the exam. Please make sure you are subscribed to our newsletter (it’s completely FREE) to get notified on future updates of this article.

 

📚  Write an article today

The Paradigm Shift Group is a community website, where everyone can publish materials related to study. The goal is to provide high quality FREE study materials created, edited and studied by academic people (students, researchers and professionals). You find more information on this page. Email the article to theparadigmshiftgroup@gmail.com admin@theparadigmshiftgroup.com.

3 Comments

  • Mukherjee Narayan Reply

    Very recently an article of Nature Medicine emphasized the importance of coffee in prevention of cellular ageing, very soon I am going to publish a brief review on this discovery for everyone here. and thank you @Arnab for explaining the mechanism with the diagram, I just want to add a few textbook references in the comment section, so that you can add those in the article later.

  • Robin Williams Reply

    I hate to see how some bloggers in other websites are telling people that taking a load of coffee each day will make you live longer. It is completely an exaggeration and far from the truth. @narayan, I encourage you to write a scientific review as soon as possible.

Feel free to comment here,