The medical literature abounds with terminologies, many of which were named after scientists, physicians or patients. It’s not surprising to get confused when someone comes across different medical conditions named after the same person or different persons with similar names.
One such example is “Paget’s disease” and a few other conditions named after James Paget. He was one of the most famous surgeon and pathologist whose contributions to these fields are still remembered with respect. You can find a short biography of him on Wikipedia. The James Paget Hospital in England was named after him.
Medical Terminologies Containing the Word “Paget” –
- Paget’s disease of bone
- Paget’s sarcoma
- Paget’s disease of breast
- Paget cell
- Extramammary Paget’s disease
- Paget-Schoetter disease
Here is a brief description of all four conditions to avoid confusion –
Paget’s disease of bone
Most common confusion occurs between Paget’s disease of bone and Paget’s disease of the breast. The term “Paget’s disease” commonly signifies the Paget’s disease of bone. In Harrison’s Principles of Internal Medicine (19th) this disease is defined as a
“localized bone-remodeling disorder that affects widespread, noncontiguous areas of the skeleton”.
The pathogenesis involves more than normal osteoclastic activity leading to increased bone resorption followed by osteoblastic bone reformation. Repeated remodeling of bones in specific sites leads to bony deformity and weakening (lamellated bone). Chronic Paget’s disease may lead to malignant changes in the affected bones.
A rare form of bone tumor that occurs secondary to chronic Paget’s disease in the affected bones. This disease has a very poor prognosis. It is a destructive bone lesion. Further information on this condition can be found here.
Paget’s disease of breast
This disease involves nipples and areola of female breasts (also called Paget’s disease of the nipple). The lesion resembles eczema but involves unilateral breast usually in elderly (more than 50 years age), while eczema usually presents with bilateral lesions in young people.
They are found in the histopathological analysis of skin in Paget’s disease affected breast. Large cells with eccentric hyperchromic nuclei surrounded by clear cytoplasm are their characteristic.
Extramammary Paget’s disease
Uncommon malignant tumors arising in the anogenital and axillary skin. They arise from stem cells in the epidermis. Prognosis is good.
A clinical condition occurring due to thrombosis in subclavian or axillary veins after vigorous physical activity or anatomical malformation. Symptoms include claudication, Raynaud’s phenomena or gangrene (due to ischemic necrosis)
- James Paget – Wikipedia.
- Harrison’s Principles of Internal Medicine, 19th edition.
- Robbins and Cotran Pathologic Basis of Disease, Ninth edition.
- “Paget’s disease of bone” by Nephron, from Wikimedia Commons.
- “Paget Cells” and featured image by Nephron – Own work, CC BY-SA 3.0, Link
- James Paget, by Unknown – , CC BY 4.0, Link
We continuously update our articles by consulting with the author and changes in recent guidelines of the exam. Please make sure you are subscribed to our newsletter (it’s completely FREE) to get notified on future updates of this article.
Write an article today
The Paradigm Shift Group is a community website, where everyone can publish any material related to study. The goal is to provide high quality FREE study materials created, edited and studied by academic people (students, researchers and professionals). You can write an article on the form provided in the sidebar or email it to email@example.com.